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Sixty Years of Mechanical Ventilation in the Treatment of ARDS: What Lessons Should We Have Learned and Where Might We Be in 2042

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1.  Which of the following was NOT a major theme of mechanical ventilation history?
  1. Practices and technology come about only after scientific research was completed
  2. Clinical practice reflect the historical period in practices and technology were created
  3. Practices and technology usually precedes the results of scientific research
  4. Partial knowledge leads to bias, misperception and misunderstanding in clinical practice
2.  The “perfect storm” for Ventilator-Induced Lung Injury in the 1960s included all, EXCEPT:
  1. Large tidal volumes
  2. Toxic FIO2
  3. No PEEP
  4. Prone Positioning
3.  Weaning from mechanical ventilation includes the following facts, EXCEPT:
  1. Weaning techniques preceded research into respiratory muscle physiology
  2. 70% of ventilated patients have no problem resume unassisted breathing
  3. IMV is the most expedient method in facilitating weaning
  4. Work of breathing during assisted ventilation equals or exceeds normal values
4.  Which of the following statements are INCORRECT regarding right-heart protective ventilation?
  1. The right heart is a thin-walled muscle prone to failure in ARDS
  2. The Pplat goal is greater than or equal to 30 cmH2O
  3. The Pplat goal is less than or equal to 26 cmH2O
  4. The incidence of cor pulmonale in ARDS is ~20-25% and up to 50% in severe ARDS
5.  ARDS mortality includes all of the following facts, EXCEPT:
  1. 90% of ARDS mortality is due to multiple organ injury and failure
  2. “Organ cross-talk” is the exchange of inflammatory mediators between distant organs
  3. 90% of ARDS mortality is caused by refractory hypoxemia
  4. Lung-Kidney injury loop is the most common “cross-talk” injury in ARDS

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