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Why Is the Concept Of the “Baby Lung” Important When Setting Tidal Volumes in ARDS Patients?

Keith Lamb, RRT, RRT-ACCS, FAARC, FCCM

October 15, 2025

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Question

Why is the concept of the “baby lung” important when setting tidal volumes in ARDS patients?

Answer

The “baby lung” concept refers to the functional portion of aerated lung tissue in ARDS patients, which is often significantly reduced due to consolidation, collapse, or inflammation. Although clinical guidelines commonly recommend tidal volumes based on predicted body weight (e.g., 6 mL/kg), this approach assumes a normal lung volume, which may not apply in patients with ARDS. In reality, patients with similar body size may have vastly different volumes of functional lung tissue available for ventilation.

Delivering the same absolute tidal volume to two patients of the same height can result in very different mechanical stress profiles. A patient with a smaller "baby lung" will experience greater stress and strain per alveolus compared to a patient with a larger aerated lung volume. This increases the risk of ventilator-induced lung injury (VILI), making it critical to assess actual lung function, not just body size, when determining ventilator settings.

This Ask the Expert is an edited excerpt from the course, Mechanical Power at a Glancepresented by Keith Lamb, RRT, RRT-ACCS, FAARC, FCCM.


keith lamb

Keith Lamb, RRT, RRT-ACCS, FAARC, FCCM

Keith Lamb, RRT, RRT-ACCS, FAARC, FCCM, is a respiratory therapist with over 22 years of clinical experience and is currently working in the Surgery/Trauma Service at the University of Virginia Medical Center in Charlottesville, Virginia. He is a fellow of both the American Association for Respiratory Care and the American College of Critical Care Medicine. Throughout his clinical career, Keith has held positions as ECMO Director, Research Coordinator, Clinical Specialist, Team Lead, and Staff Respiratory Therapist.

He has authored peer-reviewed publications and participated as Principal Investigator on numerous research initiatives. He is a published author with expertise in areas of respiratory critical care, and lectures in global topics nationally and internationally. His research and clinical work are centered on critical airway and sedation management, mechanical ventilation, and topics that pertain to the management of patients suffering from Acute Respiratory Distress Syndrome.


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